CDK3,周期素依赖性激酶3抗体

产品编号HZ-1680R
英文名称CDK3
中文名称周期素依赖性激酶3抗体
别 名Cdk 3; Cell division kinase 3; Cell division protein kinase 3; Cyclin dependent kinase 3; p36; Cdk3; CDK3_HUMAN; CDKN3; Cell division protein kinase 3; Cyclin dependent kinase 3; Cyclin-dependent kinase 3; OTTHUMP00000206828; p36.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig,
CDK3,周期素依赖性激酶3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CDK3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CDK3,周期素依赖性激酶3抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

Function:
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Subunit:
Interacts with CABLES1 and CABLES2. Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.

Tissue Specificity:
Expressed in cancer cell lines and glioblastoma tissue.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.

Gene ID:
1018

CDK3,周期素依赖性激酶3抗体Database links:
Entrez Gene: 1018 Human
Omim: 123828 Human
SwissProt: Q00526 Human
Unigene: 706766 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.