Anti-KIR3DL3 Polyclonal Antibody

品牌：solarbio | 货号：K001830P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001830P-50ul	solarbio	50ul	960.00元
K001830P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-KIR3DL3 Polyclonal Antibody
别名	CD158Z;KIR3DL7;KIR44;KIRC1
应用	WB IHC
稀释比例	WB 1:500-2000. IHC 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	45kDa
Gene ID	115653
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human KIR3DL3
性状	液体
Public Immunogen Range	Recombinant protein of human KIR3DL3
Subcellular Locations	Cell membrane Single-pass type I membrane protein
Swiss Prot	Q8N743
克隆类型	Polyclonal Antibody
背景资料	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.