FITC标记的1号染色体开放阅读框80抗体
产品名称： FITC标记的1号染色体开放阅读框80抗体
英文名称： Anti-C1orf80/FITC
产品编号： HZ-9802R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-C1orf80/FITC Conjugated antibody
FITC标记的1号染色体开放阅读框80抗体
| 产品编号 | bs-9802R-FITC |
| 英文名称 | Anti-C1orf80/FITC |
| 中文名称 | FITC标记的1号染色体开放阅读框80抗体 |
| 别 名 | dorsalization-associated protein; AIDA; AIDA_HUMAN; Axin interaction partner and dorsalization antagonist; Axin interactor; Axin interactor, dorsalization associated; Chromosome 1 open reading frame 80; UPF0491 protein C1orf80. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C1orf180/AIDA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: AIDA, also known as C1orf80, is a 306 amino acid protein that belongs to the axin interactor family. Expressed in a variety of tissues, including skeletal muscle and heart, AIDA functions as a ventralizing factor during embryogenesis, disrupting Axin homodimerization and inhibiting Axin-mediated JNK activation. Axin, a scaffold protein, is important for both JNK signaling and the canonical Wnt pathway, two processes that play an essential role in embryonic dorsoventral patterning. Disruption of Axin by AIDA results in the negative regulation of JNK and Wnt signaling, thereby affecting embryonic developmental events. Three isoforms of AIDA exist due to alternative splicing events. Function: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Subunit: Interacts with AXIN1 (By similarity). Tissue Specificity: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. Similarity: Belongs to the AIDA family. Database links: Entrez Gene: 64853 Human Omim: 612375 Human SwissProt: Q96BJ3 Human Unigene: 156625 Human Unigene: 534965 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
AIDA，又称C1ORF 80，是属于Axin相互作用家族的306氨基酸蛋白。AEDA在多种组织中表达，包括骨骼肌和心脏，在胚胎发生过程中起着腹化因子的作用，破坏Axin同质二聚和抑制Axin介导的JNK活化。Axin，支架蛋白，是重要的JNK信号和规范Wnt通路，这两个过程中起着至关重要的作用在胚胎背腹图案化。AIDA破坏Axin导致JNK和Wnt信号的负调控，从而影响胚胎发育事件。AIDA的三种异构体由于选择性剪接事件而存在。