FITC标记的原钙粘蛋白12抗体
产品名称： FITC标记的原钙粘蛋白12抗体
英文名称： Anti-PCDHA12/FITC
产品编号： HZ-5825R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHA12/FITC Conjugated antibody
FITC标记的原钙粘蛋白12抗体
| 英文名称 | Anti-PCDHA12/FITC |
| 中文名称 | FITC标记的原钙粘蛋白12抗体 |
| 别 名 | PCDH alpha 12; PCDH alpha12; PCDHA12; PCDHA 12; PCDHA-12; Protocadherin alpha 12; PCDAC_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 99kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHA12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 56137 Human Entrez Gene: 192164 Mouse Entrez Gene: 116779 Rat Omim: 606318 Human SwissProt: Q9UN75 Human SwissProt: Q91Y18 Mouse SwissProt: Q767I0 Rat Unigene: 199343 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是原粘蛋白α基因簇的成员，是与五号染色体连锁的三个相关基因簇之一，显示出与B细胞和T细胞受体基因簇相似的不寻常的基因组组织。α基因簇由15个与小鼠CNR基因有关的钙粘蛋白超家族基因组成，由13个高度相似和2个更远近的编码序列组成。15个N-末端外显子或可变外显子的串联阵列后面是下游的C-末端外显子，或恒定的外显子，由集群中的所有基因共享。大的、不间断的N-末端外显子每个编码六个钙粘蛋白胞外结构域，而C-末端外显子编码胞质结构域。这些神经钙黏附素样细胞粘附蛋白是最有可能在脑中特定细胞-细胞连接的建立和功能中发挥关键作用的完整的质膜蛋白。已经观察到选择性剪接，并且已经提出了其他变体，但它们的全长性质尚未确定。[ RefSeq，JUL 2008 ]